Publications

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72. A comprehensive review of microfluidic approaches in cell-free synthetic biology.


Frontiers in Synthetic Biology, DOI: 10.3389/fsybi.2024.1397533

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71. Targeting protein-ligand neosurfaces using a generalizable deep learning approach


bioRxiv, DOI: 10.1101/2024.03.25.585721

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69. C2CAplus: A One-Pot Isothermal Circle-to-Circle DNA Amplification System


bioRxiv, DOI: 10.1101/2023.06.26.546530

ACS Synthetic Biology, DOI: 10.1021/acssynbio.3c00390

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68. On biochemical constructors and synthetic cells


Interface Focus, DOI: 10.1098/rsfs.2023.0014

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67. A field-capable rapid plant DNA extraction protocol using microneedle patches for botanical survey and monitoring


bioRxiv, DOI: 10.1101/2023.01.09.523204

Applications in Plant Sciences, DOI: 10.1002/aps3.11529

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66. Improved cell-free transcription-translation reactions in microfluidic chemostats augmented with hydrogel membranes for continuous small molecule dialysis


bioRxiv, DOI: 10.1101/2022.08.23.504913

ACS Synthetic Biology, DOI: 10.1021/acssynbio.2c00453

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65. Direct encapsulation of biomolecules in semi-permeable microcapsules produced with double-emulsions


bioRxiv, DOI: 10.1101/2022.06.23.497329

Scientific Reports, DOI: 10.1038/s41598-022-25895-8

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64. Clinical sensitivity and specificity of a high-throughput microfluidic nano-immunoassay combined with capillary blood microsampling for the identification of anti-SARS-CoV-2 Spike IgG serostatus


medRxiv, DOI: 10.1101/2022.06.09.22276142

PLoS One, DOI: 10.1371/journal.pone.0283149

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63. Perfect adaptation achieved by transport limitations governs the inorganic phosphate response in S. cerevisiae


bioRxiv, DOI: 10.1101/2022.05.26.493535

PNAS, DOI: 10.1073/pnas.2212151120

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62. An automated do-it-yourself system for dynamic stem cell and organoid culture in standard multi-well plates


Cell Reports Methods, DOI: 10.1016/j.crmeth.2022.100244

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61. Epidemiological investigation of a SARS-CoV-2 Omicron variant outbreak in a primary school


The Lancet Infectious Diseases, DOI: 10.1016/S1473-3099(22)00267-5

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60. Biochemistry of aminoacyl tRNA synthetase and tRNAs and their engineering for cell-free and synthetic cell applications


Zenodo.org, DOI: 10.5281/zenodo.6452569

Frontiers in Biotechnology and Bioengineering, DOI: 10.3389/fbioe.2022.918659

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59. Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance


bioRxiv, DOI: 10.1101/2021.12.17.473130

Nature Communications, DOI: 10.1038/s41467-022-32971-0

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58. Epidemiological, virological and serological investigation into a SARS-CoV-2 outbreak (Alpha variant) in a primary school in Geneva, Switzerland: a prospective longitudinal study


medRxiv, DOI: 10.1101/2021.10.26.21265509

PLoS One, DOI: 10.1371/journal.pone.0272663


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57. High-throughput single-cell TCR - pMHC dissociation rate measurements performed by an autonomous microfluidic cellular processing unit


BioRxiv, DOI: 10.1101/2021.06.30.450499

ACS Sensors, DOI: 10.1021/acssensors.1c01935

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56. OnePot PURE Cell-Free System


JoVE, DOI: 10.3791/62625

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55. CFPU: a cell-free processing unit for high-throughput, automated in vitro circuit characterization


bioRxiv, DOI: 10.1101/2020.12.04.411470

BioDesign Research, DOI: 10.34133/2021/2968181

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54. A high-throughput microfluidic nano-immunoassay for detecting anti-SARS-CoV-2 antibodies in serum or ultra-low volume dried blood samples


medRxiv, DOI: 10.1101/2020.10.07.20208280

PNAS, DOI: 10.1073/pnas.2025289118

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53. Nature-inspired Circular-economy Recycling (NaCRe) for Proteins: Proof of Concept


bioRxiv, DOI: 10.1101/2020.09.23.309799

Advanced Materials, DOI: 10.1002/adma.202104581

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52. A partially self-regenerating synthetic cell


bioRxiv, DOI: 10.1101/2020.07.03.185900

Nature Communications, DOI: 10.1038/s41467-020-20180-6

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51. Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory


Molecular Cell, DOI: 10.1016/j.molcel.2020.04.016

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50. Bottom-up construction of complex biological systems with cell-free synthetic biology


Preprint DOI: 10.5281/zenodo.3591964

Frontiers in Biotechnology and Bioengineering DOI: 10.3389/fbioe.2020.00213

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49. How single-cell immunology is benefitting from microfluidic technologies.


Preprint DOI: 10.5281/zenodo.3529331

Microsystems and Nanoengineering DOI: 10.1038/s41378-020-0140-8

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48. Microfluidic systems for cancer diagnostics.


Preprint DOI: 10.5281/zenodo.3521198

Current Opinion in Biotechnology DOI: 10.1016/j.copbio.2019.11.022

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47. A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression.


Jove

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46. Steady-state cell-free gene expression with microfluidic chemostats.


protocols.io DOI: 10.17504/protocols.io.46wgzfe
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Methods in Molecular Biology DOI: 10.1007/978-1-0716-1032-9_9

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45. Cascaded amplifying circuits enable ultrasensitive cellular sensors for toxic metals.


Nature Chemical Biology DOI: 10.1038/s41589-019-0244-3
Featured: U. Edinburgh News, EurekAlert, Phys.org, Yahoo! News.
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44. A simple, robust, and low-cost method to produce the PURE cell - free system.


bioRxiv DOI: 10.1101/420570
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ACS Synthetic Biology DOI: 10.1021/acssynbio.8b00427
Featured: Most Read Articles List.
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43. Cell-free gene regulatory network engineering with synthetic transcription factors.


bioRxiv DOI: 10.1101/247627
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PNAS DOI: 10.1073/pnas.1816591116

Featured: EPFL News, EurekAlert, Phys.org, ScienceDaily.
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42. Microfluidic device for on-chip mixing and encapsulation of lysates.


bioRxiv DOI: 10.1101/247627
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Scientific Reports DOI: 10.1038/s41598-018-26542-x

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41. Microfluidic Transfection for High-Throughput Mammalian Protein Expression.


bioRxiv DOI: 10.1101/200261
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Methods in Molecular Biology DOI: 10.1007/978-1-4939-8730-6_13

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40. A microfluidic module for real-time generation of complex multi-molecule temporal concentration profiles.


bioRxiv DOI: 10.1101/119701
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Analytical Chemistry. DOI: 10.1021/acs.analchem.7b04099

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39. A microfluidic biodisplay.


bioRxiv DOI: 10.1101/112110
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ACS Synthetic Biology. DOI: 10.1021/acssynbio.7b00088

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38. Single Molecule Localisation and Discrimination of DNA-Protein Complexes by Controlled Translocation Through Nanocapillaries.


Nano Letters DOI: 10.1021/acs.nanolett.6b04165
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37. Microfluidic co-culture platform to quantify chemotaxis of primary stem cells


LOC DOI: 10.1039/C6LC00236F
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36. A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing.


Scientific Reports DOI: 10.1038/srep23937
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35. A Digital-Analog Microfluidic Platform for Patient-Centric Multiplexed Biomarker Diagnostics of Ultra-Low Volume Samples.


ACS Nano DOI: 10.1021/acsnano.5b07939
Featured in: , , , , ,
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34. Integrating Gene Synthesis and Microfluidic Protein Analysis for Rapid Protein Engineering.


bioRxiv. DOI: 10.1101/025239
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Nucleic Acids Research DOI: 10.1093/nar/gkv1497

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33. GreA and GreB enhance Escherichia coli RNA polymerase transcription rate in a reconstituted transcription-translation system.


bioRxiv. DOI: 10.1101/024604
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ACS Synthetic Biology. DOI: 10.1021/acssynbio.6b00017

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32. Rapid cell-free forward engineering of novel genetic ring oscillators


bioRxiv. DOI: 10.1101/018317
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eLife. DOI: 10.7554/eLife.09771

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31. Mechanically Induced Trapping of Molecular Interactions and Its Applications.


Journal of Laboratory Automation. DOI: 10.1177/2211068215578586
PDF ResearchGate
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30. A microfluidic platform for high-throughput multiplexed protein quantitation.


arXiv arXiv:1410.5377v1
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PLoS One. DOI: 10.1371/journal.pone.0117744
PDF ResearchGate
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29. Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription.


Genes & Development. DOI: 10.1101/gad.244434.114
PDF ResearchGate
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28. LSPR Chip for Parallel, Rapid, and Sensitive Detection of Cancer Markers in Serum.


Nano Letters. DOI: 10.1021/nl500574n
PDF ResearchGate
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26. A 1,024-sample serum analyzer chip for cancer diagnostics.


Lab on a Chip. DOI: 10.1039/C3LC51153G.
Featured in: LOC Top 10%, ChemistryWorld, LOC most downloaded articles, Lab on a Chip Blog
PDF ResearchGate
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25. Implementation of cell-free biological networks at steady-state.


PNAS 110(40):15985-15990. DOI: 10.1073/pnas.1311166110

PDF ResearchGate
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24. A chemostat array enables the spatio-temporal analysis of the yeast proteome.


PNAS 110(39):15614-15619. DOI:10.1073/pnas.1308265110
Featured in: LOC Research Highlights, Molecular Systems Biology Editor's Selection, GenomeWeb
PDF ResearchGate
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23. Mapping the fine structure of a eukaryotic promoter input-output function.


Nature Genetics 45(10):1207-1215. DOI:10.1038/ng.2729
Featured in: Nature Methods, EPFL News, Scicasts, MedicalExpress, Radio Canada
PDF ResearchGate
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22. Live Mammalian Cell Arrays.


Nature Methods 10(6):550-552. DOI:10.1038/nmeth.2473.
Highlighted in: Faculty of 1000
PDF ResearchGate
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21. A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening.


Integrative Biology 5(4):650-658. DOI: 10.1039/C3IB20263A
Featured in: Inside Front Cover, Most Read Articles, Top Ten Most Accessed Papers in Q2 2013
PDF ResearchGate
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20. Real-time mRNA measurement during an in vitro transcription and translation reaction using binary probes.


ACS Synthetic Biology 2(8):411-417. doi: 10.1021/sb300104f

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19. iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks.


Nucleic Acids Research 41(4):e52. doi:10.1093/nar/gks1323

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18. Multiplexed surface micropatterning of proteins with a pressure-modulated microfluidic button-membrane.


Chem. Commun 49(13):1264-1266. doi:10.1039/C2CC37740C
Featured in: Inside Front Cover
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17. Massively Parallel Measurements of Molecular Interaction Kinetics on a Microfluidic Platform.


PNAS 109(41):16540-16545. doi:10.1073/pnas.1206011109
Featured in: Radio Canada, EPFL News, Science Daily, American Society for Biochemistry and Molecular Biology Blog, Phys.org
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16. Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit.


PLoS Biology 10(7): e1001364. doi:10.1371/journal.pbio.1001364
Highlighted in: Nature Reviews Genetics
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15. Rapid Synthesis Of Defined Eukaryotic Promoter Libraries.


ACS Synthetic Biology 1(10):483-490. doi:10.1021/sb300045j
Highlighted in: Top 5 most read articles
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14. Probing the Informational and Regulatory Plasticity of a Transcription Factor DNA–Binding Domain.


PLoS Genetics, 8(3): e1002614. doi:10.1371/journal.pgen.1002614

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12. MITOMI: A Microfluidic Platform for In Vitro Characterization of Transcription Factor-DNA Interaction.


Methods in Molecular Biology, 786:97-114.

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10. A software-programmable microfluidic device for automated biology.


Lab on a Chip, 11:p. 1612.
Featured in: Top 10 most accessed paper in March 2011
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7. Experimental determination of the evolvability of a transcription factor.


PNAS, 106(44):p. 18650-5
Highlighted in: Faculty of 1000
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6. Integration of plasmonic trapping in a microfluidic environment.


Optics Express, 17(8): p. 6018-24

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5. An in vitro microfluidic approach to generating protein-interaction networks.


Nature Methods, 6(1): p. 71-4

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4. Integration column: Microfluidic high-throughput screening.


Integrative Biology, 1(1): p. 19-29

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3. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis.


Nature Biotechnology, 26(9): p. 1019-1027
Featured in: Cover, Chemistry World
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2. A systems approach to measuring the binding energy landscapes of transcription factors.


Science, 315(5809): p. 233-237
Highlighted in: Scientific American, Chemical & Engineering News, HHMI News, Nature Methods, Biopolymers
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1. Microfluidic large-scale integration.


Science, 298(5593): p. 580-584
Highlighted in: Cover, Science Express, Highlighted in: Faculty of 1000, Chemical & Engineering News, Nature Science Update, Technology Research News, Science Watch Top 10, ESI-Topics: Microfluidic Devices Top 10 papers (2007)
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* these authors contributed equally