Research
Nano Letters
09.11.16 — A Single Molecule Localisation and Discrimination of DNA-Protein Complexes by Controlled Translocation Through Nanocapillaries
Nano Letters published our manuscript:"Single Molecule Localisation and Discrimination of DNA-Protein Complexes by Controlled Translocation Through Nanocapillaries." Nano Letters website
Nano Letters published our manuscript:"Single Molecule Localisation and Discrimination of DNA-Protein Complexes by Controlled Translocation Through Nanocapillaries." Nano Letters website
Research
Scientific Reports
31.03.16 — A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing
Scientific Reports published our manuscript:"A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing." ACS Nano website
Scientific Reports published our manuscript:"A High-Throughput Microfluidic Platform for Mammalian Cell Transfection and Culturing." ACS Nano website
Research
ACS Nano
07.01.16 — A Digital-Analog Microfluidic Platform for Patient-Centric Multiplexed Biomarker Diagnostics of Ultra-Low Volume Samples
ACS Nano just published our manuscript:"A Digital-Analog Microfluidic Platform for Patient-Centric Multiplexed Biomarker Diagnostics of Ultra-Low Volume Samples." ACS Nano website
ACS Nano just published our manuscript:"A Digital-Analog Microfluidic Platform for Patient-Centric Multiplexed Biomarker Diagnostics of Ultra-Low Volume Samples." ACS Nano website
Research
Nucleic Acids Research
23.12.15 — Integrating gene synthesis and microfluidic protein analysis for rapid protein engineering
Nucleic Acids Research just published our bioRxiv preprint:"Integrating gene synthesis and microfluidic protein analysis for rapid protein engineering." NAR website
Nucleic Acids Research just published our bioRxiv preprint:"Integrating gene synthesis and microfluidic protein analysis for rapid protein engineering." NAR website
Research
eLife
2.10.15 — Rapid cell-free forward engineering of novel genetic ring oscillators
eLife just published our bioRxiv preprint:"A cell-free framework for biological systems engineering." PLoS One website
eLife just published our bioRxiv preprint:"A cell-free framework for biological systems engineering." PLoS One website
Funding
SystemsX.ch Special Op
16.07.2015 — SystemsX.ch approves Special opportunity project
SystemsX.ch approved our Special Opportunity grant proposal on "Development of a high-throughput platform for systems immunology and protein engineering". This grant will support our efforts in developing next generation methods for protein engineering. SystemsX.ch website
SystemsX.ch approved our Special Opportunity grant proposal on "Development of a high-throughput platform for systems immunology and protein engineering". This grant will support our efforts in developing next generation methods for protein engineering. SystemsX.ch website
Research
bioRxiv
21.04.15 — A cell-free framework for biological systems engineering.
We just deposited a preprint of our manuscript describing our recent collaborative work with the Murray group on engineering biological networks in vitro. PLoS One website
We just deposited a preprint of our manuscript describing our recent collaborative work with the Murray group on engineering biological networks in vitro. PLoS One website
Funding
HFSP Grant Award
24.03.15 — HFSP Program Grant Award
We have been awarded a three year HFSP Program Grant for "Establishing microfluidic cell-free systems for the rapid characterization of genetic networks" in collaboration with Richard Murray's laboratory at Caltech.
HFSP Program Grants support "innovative basic research into fundamental biological problems with emphasis placed on novel and interdisciplinary approaches that involve scientific exchanges across national and disciplinary boundaries." HFSP Program Grants are highly competitive with a success rate of ~3%.
Research Grant Awardees 2015
Research
PLoS One
23.02.15 — A Microfluidic Platform for High-Throughput Multiplexed Protein Quantitation
We deomnstrate a highly multiplexed microfluidic immunoassay platform capable of measuring up to 384 distinct biomarkers in parallel and applied it to immunoassay optimization. PLoS One website
We deomnstrate a highly multiplexed microfluidic immunoassay platform capable of measuring up to 384 distinct biomarkers in parallel and applied it to immunoassay optimization. PLoS One website
News Coverage / Award
Nature Methods 10 year Anniversary Cover
29.09.14 — LBNC images featured on the Anniversary Cover
Kristina submitted two images of fluorescent mammalian cells arrayed into a nano-well array in the shape of a "10". Both images were included on the 10 year Anniversary Cover of Nature Methods. The original high-resolution files can be downloaded here (grey scale version) and here (red version). Nature Methods website
Kristina submitted two images of fluorescent mammalian cells arrayed into a nano-well array in the shape of a "10". Both images were included on the 10 year Anniversary Cover of Nature Methods. The original high-resolution files can be downloaded here (grey scale version) and here (red version). Nature Methods website
Funding
SystemsX.ch IPhD
21.08.14 — SystemsX.ch approves IPhD project
SystemsX.ch approved an IPhD grant proposal in collaboration with Prof. Shore at the University of Geneva. The title of the proposal is "Comprehensive analysis of transcription factor - promoter interaction in vitro and in vivo" and will allow us to quantitatively investigate fundamental biophysical aspects of transcriptional regulation in the model organism S. cerevisiae. SystemsX.ch website
SystemsX.ch approved an IPhD grant proposal in collaboration with Prof. Shore at the University of Geneva. The title of the proposal is "Comprehensive analysis of transcription factor - promoter interaction in vitro and in vivo" and will allow us to quantitatively investigate fundamental biophysical aspects of transcriptional regulation in the model organism S. cerevisiae. SystemsX.ch website
Research
Genes & Development
01.08.14 — Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription
Britta Knight of the Shore Lab in collaboration with our lab published and article in Genes & Development: Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription.
Read the whole article
Research
Nano Letters
01.08.14 — LSPR Chip for Parallel, Rapid, and Sensitive Detection of Cancer Markers in Serum
In collaboration with the Quidant lab (ICFO) we published a paper in Nano Letters: LSPR Chip for Parallel, Rapid, and Sensitive Detection of Cancer Markers in Serum.
Read the whole article
Research
PLoS One
14.04.14 — Long-Term Single Cell Analysis of S. pombe on a Microfluidic Microchemostat Array
Jean-Bernard's paper Long-Term Single Cell Analysis of S. pombe on a Microfluidic Microchemostat Array is now published in PLoS One.
Read the whole article
News Coverage
LOC Research Highlights
January 2014 — Nicolas' microchemostat paper published in PNAS was featured in LOC Research Highlights.
Read the whole article
News Coverage
LOC Research Highlights
January 2014 — Jose's paper was inducted into the LOC Top 10%
Read the whole article
News Coverage
LOC Blog
07.04.14 — Our paper: "A 1,024-sample serum analyzer chip for cancer diagnostics" is currently one of the most downloaded articles at LOC and was featured in their blog.
Read the whole article
News Coverage
Chemistry World
December 2013 — Chemistry World featured our paper: "A 1,024-sample serum analyzer chip for cancer diagnostics."
Read the whole article
Research
Lab on a Chip
November 2013 — A 1,024-sample serum analyzer chip for cancer diagnostics
Jose published a manuscript in Lab on a Chip describing an ultra high-throughput microfluidic platform for use in cancer diagnostics: A 1,024-sample serum analyzer chip for cancer diagnostics.
Read the whole article
Award
New Frontiers in Synthetic Life
November 2013 — Henrike won one of three best poster prizes at the meeting New Frontiers in Synthetic Life. Congratulations!
Read the whole article
Teaching / News Coverage
Popular Science
November 2013 — Popular Science features Taxi. coli as one of the coolest iGEM projects of 2013.
Read the whole article
News Coverage
Integrative Biology
October 2013 — Our paper "A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening." is one of the top ten most accessed articles at Integrative Biology in Q2 2013.
Read the whole article
Teaching / Awards
iGEM
October 2013 — Congratulations to our 2013 EPFL iGEM team for winning a Silver Medal and, more importantly, for qualifying for the iGEM World Championship held at MIT.
Read the whole article
Research
Proceedings of the National Academy of Sciences
September 2013 — Implementation of cell-free biological networks at steady state
PNAS published Henrike's paper on running biological networks in a cell free, completely defined environment: "Implementation of cell-free biological networks at steady state."
Read the whole article
Research
Proceedings of the National Academy of Sciences
September 2013 — A chemostat array enables the spatio-temporal analysis of the yeast proteome
PNAS published our microchemostat platform with which we measured the flux of the yeast proteome on the single cell level: "A chemostat array enables the spatio-temporal analysis of the yeast proteome."
Read the whole article
Conference
Physical Biology of Transcription
August 2013 — We are organizing a meeting on transcription, which will take place on 30-08-2013 at the University of Geneva. The one day symposium features the following speakers: Curtis Callan (Princeton), Barak Cohen (Wash. U.), Johan Elf (Uppsala U.), Jason Lieb (Princeton), Eran Segal (Weizmann Institute), and David Suter (EPFL). Attendance is free, and talks will begin at 10am in room A100 in Sciences II.
Read the whole article
Research
Nature Genetics
August 2013 — Mapping the fine structure of a eukaryotic promoter input-output function
Nature Genetics published Arun's promoter architecture paper: "Mapping the fine structure of a eukaryotic promoter input-output function"
Read the whole article
Research
Nature Methods
May 2013 — Live Mammalian Cell Arrays
Kristina and Luis, in collaboration with the Lutolf lab published a paper in Nature Methods describing a simple process for generating high-density mammalian cell arrays: "Live Mammalian Cell Arrays."
Read the whole article
Cover
Integrative Biology
March 2013 — Jose's and Chiara's paper in Integrative Biology has been featured on the inside front cover!
Read the whole article
News Coverage
Reuters News
March 2013 — Jose's and Francesca's research was featured on a short clip on Reuters TV. Watch on the Reuters site
Read the whole article
Research
Integrative Biology
February 2013 — A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening.
Jose, in collaboration with Chiara Nembrini and the Hubbell lab published a paper in Integrative Biology describing a high-throughput nanoimmunoassay platform and its application to adjuvant screening: "A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening."
Read the whole article
Cover
Chemical Communications
January 2013 — Jose's paper in Chemical Communication was featured on the inside front cover!
Read the whole article
Research
ACS Synthetic Biology
December 2012 — Real-time mRNA measurement during an in vitro transcription and translation reaction using binary probes.
Henrike Niederholtmeyer published an article in ACS Synthetic Biology describing a method for measuring mRNA levels in real-time in an in vitro transcription / translation reaction: "Real-time mRNA measurement during an in vitro transcription and translation reaction using binary probes."
Read the whole article
Research
Nucleic Acids Research
December 2012 — iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks
Sylvie Rockel published an article in Nucleic Acids Research describing a MITOMI based gene-centric approach for characterizing transcriptional regulatory networks: "iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks."
Read the whole article
Research
Chemical Communications
November 2012 — Multiplexed surface micropatterning of proteins with a pressure-modulated microfluidic button-membrane.
Jose Garcia-Cordero published an article in Chemical Communications describing a novel approach for the multiplexed micro-patterning of proteins using a microfluidic device: "Multiplexed surface micropatterning of proteins with a pressure-modulated microfluidic button-membrane."
Read the whole article
Research
Proceedings of the National Academy of Sciences
September 2012 — Massively Parallel Measurements of Molecular Interaction Kinetics on a Microfluidic Platform
We published an article in PNAS describing a microfluidic platform capable of obtaining 768 kinetic rate measurements in parallel: "Massively Parallel Measurements of Molecular Interaction Kinetics on a Microfluidic Platform." The article was also covered in: Radio Canada, EPFL News, Science Daily, American Society for Biochemistry and Molecular Biology Blog, Phys.org
Read the whole article
Research
PLoS Biology
July 2012 — Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit
Christian Schroeter from the Oates Lab at the MPI-CBG in collaboration with our and the Deplancke Labs published a paper in PLoS Biology: "Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit."
Read the whole article
Research
ACS Synthetic Biology
June 2012 — Rapid Synthesis Of Defined Eukaryotic Promoter Libraries
Arun published an article in ACS Synthetic Biology describing a method for the "Rapid Synthesis Of Defined Eukaryotic Promoter Libraries"
Read the whole article
Research
PLoS Genetics
March 2012 — Probing the Informational and Regulatory Plasticity of a Transcription Factor DNA–Binding Domain
Ryan Schultzaberger of the Eisen lab at UC Berkeley in collaboration with the Maerkl Lab published a paper in PLoS Genetics: "Probing the Informational and Regulatory Plasticity of a Transcription Factor DNA–Binding Domain"
Read the whole article
Award
1st International SystemsX.ch conference
October 2011 — Marcel Geertz won the Best Poster Award at the 1st International SystemsX.ch conference with his poster: "A microfluidic platform for massively parallel measurements of biomolecular interaction kinetics"
Read the whole article
Workshop
Microfluidic Workshop
August 2011 — Microfluidic Technology Workshop 2011: follow this link for more information (registration is now closed).
Read the whole article
Research
PLoS Genetics
April 2011 — Does Positive Selection Drive Transcription Factor Binding Site Turnover? A Test with Drosophila Cis-Regulatory Modules
Bin He from the Kreitman lab at U. Chicago, in collaboration with the LBNC, has published a paper in PLOS Genetics: "Does Positive Selection Drive Transcription Factor Binding Site Turnover? A Test with Drosophila Cis-Regulatory Modules."
Read the whole article
Research
Lab on a Chip
28.10.11 — A software-programmable microfluidic device for automated biology
We published a paper in Lab on a Chip describing a fully software-programmable device. Read about it
Read the whole article
Teaching
Engineering Life – a new generation of students emerges
October 2010 — LBNC in the news: Engineering Life – a new generation of students emerges. Read the full EPFL news report
Read the whole article
Research
Nature Biotechnology
January 2009 — An in vitro microfluidic approach to generating protein-interaction networks
We have developed a novel microfluidic method for the rapid determination of protein - protein interactions, the results are published in Nature Methods.
Read the whole article
Research / Cover
Nature Biotechnology
August 2008 — Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis
Read our Nature Biotechnology article describing the application of MITOMI to high-throughput drug discovery targeting a Hepatitis C membrane protein.
Read the whole article